How Do Purified Peptides Stack Up Against Retinol For Anti-Aging? We Asked A Dermatologist

When it comes to anti-aging products, retinol has been one of the top ingredients in skincare. The vitamin A derivative is an over-the-counter version of its stronger counterpart, retinoids, which require a prescription, per Cleveland Clinic. You can find retinol in many moisturizers and serums, as it's a generally safe product that helps with fine lines and wrinkles, while also creating more collagen in the skin. Retinol doesn't come without its cons, however. What you need to know before using retinol is that those with sensitive skin may experience irritation and redness.

The good news is that there are other options to fight aging skin. Peptides have been around in skincare for decades but its newest purified form is looking to be a powerhouse for anti-aging. So what exactly are purified peptides? Dr. Aanand Geria of Geria Dermatology exclusively explained to Glam, "Peptides in skincare are short chains of amino acids that can have various beneficial effects on the skin. Purified peptides used in skincare products undergo a purification process to ensure a high level of purity and effectiveness." He continued, "The rationale for using purified peptides in skincare is that they can provide specific benefits to the skin by promoting collagen production, improving skin texture, or assisting in other skin-renewal processes." So, which is better for reversing time on one's face? While purified peptides and retinol each have their benefits, peptides may be an overall better fit for many.

Both purified peptides and retinol are known to reduce the appearance of aging but they both work in different ways. Dr. Aanand Geria exclusively told us, "Purified peptides, short amino acid chains, stimulate collagen for improved elasticity. They are generally well-tolerated and suitable for sensitive skin." The board-certified dermatologist added, "On the other hand, retinols, derived from Vitamin A, enhance cell turnover and collagen but may cause sensitivity and are recommended for evening use."

Some using retinol for the first time can experience something called "retinol burn," per Healthline. The product can take some time to get used to and at first, users may see redness, flaking, and feel irritation. Because retinol works to get rid of dead skin cells, new cells may not be generated fast enough, thus making your skin raw. Dr. Geria also warned that retinol can interact with other ingredients, while peptides don't cause a reaction when used with other products. However, he stated, "Retinol is considered the gold standard based on decades of scientific research, whereas peptides are a newer anti-aging ingredient."

While peptides in skincare are nothing new, it seems that the purified peptides are fairly recent and only Cetaphil carries products with the ingredient, as of this writing. Dr. Aanand Geria suggests trying out Cetaphil Healthy Renew Purified Peptides Night Cream, although the brand has other options, such as an eye serum and a daytime moisturizer with SPF 30. The good news is that purified peptides are good for all skin types. "Even those with sensitive skin," Dr. Geria exclusively told Glam. "These are usually applied twice a day as a serum or cream after washing your face," he added.

Of course, if you're a die-hard retinol fan, you'll be happy to know it's better when used with peptides. Dermatologist Dr. Kavita Mariwalla shared with Real Simple, "You get the collagen-building effects of the retinoid, but it also works to improve the penetration of the peptide cream, which can help improve skin's firmness." An added bonus is that the hydrating components of products containing peptides can help soothe any irritation from the retinol, so it turns out, you don't have to pick one or the other.